Alexandra M Mowday Selected Research

Nitroreductases

2/2022	Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications.
1/2019	Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
1/2016	Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy.
6/2013	Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.
4/2013	Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

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Alexandra M Mowday Research Topics

Disease

13	Neoplasms (Cancer) 02/2022 - 03/2012
7	Hypoxia (Hypoxemia) 02/2022 - 03/2012
3	Disease Progression 03/2017 - 02/2014
1	Necrosis 01/2022
1	Colonic Neoplasms (Colon Cancer) 01/2022
1	Brain Neoplasms (Brain Tumor) 06/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2016
1	Carcinoma (Carcinomatosis) 04/2013

Drug/Important Bio-Agent (IBA)

11	ProdrugsIBA 02/2022 - 03/2012
6	EnzymesIBA 01/2019 - 04/2013
5	NitroreductasesIBA 02/2022 - 04/2013
3	PR-104AIBA 02/2022 - 11/2021
2	Phosphates (Orthophosphate)IBA 02/2022 - 01/2016
2	Oxidoreductases (Dehydrogenase)IBA 11/2021 - 02/2014
2	azomycinIBA 01/2019 - 03/2012
1	vadimezanIBA 01/2022
1	A-Form DNA (A-DNA)IBA 12/2021
1	Antineoplastic Agents (Antineoplastics)IBA 12/2021
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 11/2021
1	Temozolomide (Temodar)FDA LinkGeneric 06/2020
1	LuciferasesIBA 06/2020
1	SN33623IBA 01/2019
1	4-nitroimidazoleIBA 01/2019
1	SN34507IBA 01/2016
1	SN35539IBA 01/2016
1	PR-104IBA 01/2016
1	OxidesIBA 02/2014
1	Nitro CompoundsIBA 02/2014
1	Oxygen (Dioxygen)IBA 02/2014
1	Cytotoxins (Cytolysins)IBA 02/2014
1	QuinonesIBA 02/2014
1	Coordination ComplexesIBA 02/2014
1	Proteins (Proteins, Gene)FDA Link 04/2013
1	isophosphamide mustard (IPAM)IBA 03/2012
1	DNA (Deoxyribonucleic Acid)IBA 03/2012
1	NucleotidesIBA 03/2012
1	TH 302IBA 03/2012

Therapy/Procedure

7	Therapeutics 06/2020 - 04/2013
2	Immunotherapy 01/2022 - 01/2021
1	Radiotherapy 02/2014